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Adapin (Doxepin)

Adapin belongs to a class of drugs called tricyclic antidepressants (TCAs) that are used primarily to treat depression and anxiety. Other examples of TCAs include amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), and several others. Depression is an all-pervasive sense of sadness and gloom. In some patients with depression, an imbalance in levels of neurotransmitters in the brain may be the cause of the depression. Neurotransmitters are chemicals that nerves use to communicate with each other. Neurotransmitters affected by Adapin include serotonin, norepinephrine, acetylcholine, and histamine. Adapin may elevate mood by raising the levels of serotonin and norepinephrine. It also blocks the activity of acetylcholine and histamine. The FDA approved Adapin in March 1974.

Other names for this medication:
Doxepin, Sinequan, Adapin, Anten, Aponal, Deptran, Doneurin, Doxal, Doxin, Expan, Gilex, Mareen, Quitaxon, Silenor, Sinepin, Zonalon,

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Adapin (Silenor) comes as a tablet to take by mouth. It is usually taken once a day, within 30 minutes of bedtime. Do not take Adapin (Silenor) within 3 hours of a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Adapin (Silenor) exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You will probably become very sleepy soon after you take Adapin (Silenor) and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take Adapin (Silenor) and to stay in bed for 7 to 8 hours. Do not take Adapin (Silenor) if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication.

You should begin to sleep better during the first few days of treatment with Adapin (Silenor). If your sleep does not improve within 7-10 days, or gets worse call your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Adapin (Silenor) and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( to obtain the Medication Guide.

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