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Lafigin (Lamotrigine)
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Lamotrigine

Lafigin is an important anticonvulsant with activity against both focal and generalized onset seizures. It is also effective in the treatment of bipolar disorder and neuropathic pain. However, its use is associated with a significant incidence of adverse cutaneous reactions, mainly when concomitant therapy is administered. Rash is the most common adverse reaction of this antiepileptic agent and the most common reason for treatment discontinuation as it can be life-threatening. Children under polytherapy have a higher risk of this adverse event. Such cutaneous reactions range from mild rashes to more serious conditions such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis. SJS is thought to be a hypersensitivity reaction involving skin and mucous membranes.

Other names for this medication:
Lamotrigine, Lamictal, Daksol, Epitec, Flamus, Labileno, Lafigin, Lamal, Lambipol, Lamez, Lamictin, Lamidus, Lamirax, Lamitor, Lamitrin, Lamogine, Lamolep, Lamotrigin, Lamotrigina, Lamotrix, Lomarin, Meganox,

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Lafigin extended-release (long-acting) tablets are used with other medications to treat certain types of seizures in patients who have epilepsy. All types of Lafigin tablets (tablets, orally disintegrating tablets, and chewable tablets) other than the extended-release tablets are used alone or with other medications to treat seizures in people who have epilepsy or Lennox-Gastaut syndrome (a disorder that causes seizures and often causes developmental delays). All types of Lafigin tablets other than the extended-release tablets are also used to increase the time between episodes of depression, mania (frenzied or abnormally excited mood), and other abnormal moods in patients with bipolar I disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Lafigin has not been shown to be effective when people experience the actual episodes of depression or mania, so other medications must be used to help people recover from these episodes. Lafigin is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

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Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. The second is that dietary intervention, either in the form of complete nutrition support or as single nutrient supplementation, can improve or accelerate the wound-healing response.

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The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiae. Induction of high-affinity GM-CSF receptors during all-trans retinoic acid treatment of acute promyelocytic leukemia. The Mississippi physician as an expert witness--must he accept token compensation? The data reports are concentrating on salmonellosis, tuberculosis, brucellosis and trichinellosis.

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Personality and Total Health Through Life Project Eye Substudy: Methodology and Baseline Retinal Features. Alteration in nicotinic and muscarinic responses of rabbit superior cervical ganglion cells after chronic preganglionic denervation. Our patient had developed overt parkinsonism presenting with a resting tremor, expressionless face, and lack of blinking along with marked cogwheel rigidity and a stooped, slow gait. Innate immunity in the deep sea hydrothermal vent mussel Bathymodiolus azoricus.

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We prospectively evaluated a cohort of men with prostate cancer who elected surgery with and without nerve sparing, and bladder neck preservation as primary therapy. The addition of glucose or other sugars to resting cells of Serratia maurcescens induced rapid acidification of the extracellular medium. Thus, regular caffeine drinking decreased the cocaine intake without significantly affecting its reinforcing properties, perhaps because it enhanced the activation of the predominantly inhibitory frontal cortical areas produced by low doses of cocaine. Use of the form permits the pharmacist to focus on the specific claims made by the physician who is requesting the formulary addition. The aim of this study was to demonstrate the results of a five-year screening program for SCC in HIV patients.

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Effect of 5-nitroindole on adenylate energy charge, oxidative phosphorylation, and lipid peroxidation in rat hepatocytes. Data obtained in vitro are however believed to be unaffected by such drugs.

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Ileostomy should be the first choice of anastomotic leakage after laparoscopy-assisted right hemicolectomy and its efficacy is satisfactory. Vascular pattern and spectral parameters of power Doppler ultrasound as predictors of malignancy risk in thyroid nodules. An analytical expression based on four fitting parameters is proposed for a mathematical description of electron beam central axis depth dose distributions. This theory explains the co-occurrence of stereopsis and diplopia and how half-occlusions escape the suppression characteristic of binocular rivalry. Effect of rat intrinsic factor on vitamin B12 absorption in pernicious anemia.

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We report a novel role of Wnt signaling in organogenesis using the formation of the islet during pancreatic development as a model tissue. Of 36 plant species, only two species of ferns (Pityrogramma calomelanos and Pteris vittata), a herb (Mimosa pudica), and a shrub (Melastoma malabrathricum), seemed suitable for phytoremediation. Hospital admissions among patients with congestive heart failure (CHF) are a major contributor to health-care costs.

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Regenerated egg white/silk fibroin composite films for biomedical applications. In this study, urocortin expression was evaluated by both immunohistochemistry and reverse transcription-polymerase chain reaction, in human uterine tissues and cells at different phases of the menstrual cycle. Veterans underwent structured psychiatric diagnostic interview and completed self-report measures of combat exposure, posttraumatic stress disorder (PTSD), depression, and occurrence of head injury.

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Weight reduction programmes at a rehabilitation centre and a health centre based on group counselling and individual support: short- and long-term follow-up study. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm. Quantification of insulin-like growth factor-I also manifests elevated insulin-like growth factor-I levels in silicotic rat bronchoalveolar lavage fluids which tend to increase with prolongation of silica exposure in vivo, but no alteration in insulin-like growth factor-I level can be found in sera. Synchrotron radiation circular dichroism spectroscopy of ribose and deoxyribose sugars, adenosine, AMP and dAMP nucleotides.

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In this study, snaR was identified as upregulated and to play a role in cancer progression of HER2-positive breast cancer cells. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Value of prostatic specific antigen screening in prostatic cancer The interest in improving the definitions of asthma phenotypes and endotypes is growing, although these classifications do not always correlate with prognosis nor are always appropriate therapeutic approaches. Pseudoephedrine use among US children, 1999-2006: results from the Slone survey.

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Prospective, randomized trial of trimethoprim/sulfamethoxazole vs. Here, we investigated the possibility to isolate, culture-expand and characterize the cells from the cochlea membrane of adult mice. However, the complex nature of water flow through natural and man-made courses makes it very difficult to determine accurately the limiting range of water velocity that allows the settlement and development of snail colonies in a watercourse, and results are therefore still inconclusive.This paper describes the procedure employed in and the results obtained from a study designed to elucidate the water flow phenomenon through analysis of the relative variations of water velocity at any point of the cross-section of the canal. To gain contemporary insights from residents and surgeons regarding the care of older surgical patients.

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Primary response and spontaneous electrical activity of the cerebral cortex Novel Bioactivities from a Coral, Galaxea fascicularis: DNase-like Activity and Apoptotic Activity Against a Multiple-Drug-Resistant Leukemia Cell Line. (T2AG3)n telomeric sequence hybridization indicating centric fusion rearrangements in the karyotype of the rodent oryzomys subflavus.

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The purpose of this study was to examine the influence of the fluid dynamics of syringe irrigation on the efficacy of wound cleansing and the infection rate of experimental wounds. Review of salient literature, clinical and personal experiences, conference presentations and discussions, and post-conference comments from outside experts. Tracheobronchial amyloidosis, which is not associated with evident clonal proliferation, results in airway stenoses necessitating iterative laser treatment. Symbiote-free hemoflagellates, Blastocrithidia culicis and Crithidia oncopelti: their liver factor requirement and serologic identity. In the year 2007 a group of experts come together to discuss criteria for acute cholecystitis and to establish therapeutic guidelines and states of gravity in this disease.

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There have been many well-publicized hostage, prisoner of war and politically motivated incarcerations. MicroRNA (miRNA) are short noncoding segments of RNA that posttranscriptionally regulate gene expression. K(m) for the elimination ranged in the different models from 2.5 to 5.6 microM. Ammonium chloride potentiation of streptozotocin-induced diabetes in juvenile pigs.

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Evaluation of a vessel-sealing device for use in laparoscopic ovariectomy in mares. Contribution to the interpretation of the inter- and parafollicular cells of the thyroid in various experimental conditions (observations by electron microscope) The different behavior for holes and electron transport is due to differing transport mechanisms. The effect of fluvoxamine and sertraline on the opioid withdrawal syndrome: a combined in vivo cerebral microdialysis and behavioural study. Evaluations for trans-epidermal water loss (TEWL), skin hydration and erythema were carried out at baseline, 0, 4, 8, 24, 48 and 72 hours after the treatment.

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Smad3 deficiency did not alter the response of bone marrow cells to TGF-beta1. Fibrous hamartoma tissues were surgically excised at the time of osteosynthesis from seven patients with congenital pseudarthrosis of the tibia associated with neurofibromatosis type 1. Developing cultural competence in the baccalaureate nursing student: a population-based project with the Hutterites.

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MST1 and MST2 are located in mitochondria and cytoplasm, respectively, as shown by immunoblot analysis of subcellular fractions and by green fluorescent protein (GFP) analysis. Modification of cycling biomechanics during a swim-to-cycle trial. This study demonstrates the close relationship between the epithelial cells and the immunocompetent cells in a rat periodontium, indicating a functional interrelationship. Non-pharmacologic interventions used to reduce spasticity include physiotherapy, occupational therapy, use of adaptive equipment, various orthopedic surgical procedures and neurosurgical procedures. The causative prions are found especially in neural tissues and spinal fluid, and in the case of vCJD, in lymphoreticular tissue.

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Lumbar and femoral bone mineral density (BMD) were measured at baseline and after 12 months, together with serum osteocalcin and urinary hydroxyproline. We showed that PaCa-derived CXCL8 and fibroblast-derived CXCL12 cooperatively induced angiogenesis in vitro by promoting HUVEC proliferation, invasion, and tube formation. Deanol (deaner) a new cerebral stimulant for the treatment of neurasthenia and mild depression: a preliminary report. Metastatic gastric adenocarcinoma presenting as an enlarging plaque on the scalp.

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Systemic reactions in skin diseases with special reference to C-reactive protein and sialic acid of blood serum Smoking cessation does not entirely mitigate the negative effects of smoking on baseline and postoperative PROs for patients undergoing lumbar fusion surgery. In China, sub-type B of AIH might be more frequent than sub-type C and there were differences in clinical aspects, serology and pathology between the two types.

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There has been a quiet revolution in the care of children with diabetes over the last decade. The effects of an exercise physiology program on physical fitness variables, body satisfaction, and physiology knowledge. Public Health Service and the Department of Health and Human Services provides a blueprint of health goals for the nation into the 21st century. There was transitory homonymous hemianopia (one patient), brief jerking of one arm (two patients), and affective (crying) reaction (three patients) after the end of a train of stimuli.

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Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice. Studies on the relationship between signaling systems in neurasthenia and hysteria

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On roentgenological diagnosis of calcifications of the coronary artery of the heart A comparison of operative approaches and parameters predictive of success in multilevel arterial occlusive disease.

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Contrast effect of hydrogen bonding on the acceptor and donor OH groups of intramolecularly hydrogen-bonded OH pairs in diols. The Bartha strain of pseudorabies virus was injected into the lacrimal gland, and after different survival times, the superior cervical and Gasserian ganglia, the upper thoracic spinal cords and the brainstems were immunostained by antiviral antiserum. Fluoride in groundwater in selected villages in Eritrea (North East Africa). Effects of sequential combined transdermal and oral hormone replacement therapies on serum lipid and lipoproteins in postmenopausal women.

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New Uses for Calcium Channel Blockers : Therapeutic Implications. The expression and transcription activity of cell cycle regulators c-MYC and Cyclin D1 were examined to determine the mechanism behind WNT5A regulation of chondrocyte proliferation. Suicide risk peaks in first week of psychiatric hospitalisation and post-discharge. To assess the physiological, biochemical and haemodynamic response to a single intravenous (IV) dose of frusemide in critically patients.

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Coherence does not demonstrate a progressive increase in the organization of atrial fibrillation prior to termination. The key features in the CoMFA contour maps are critical to trace the important properties and gain insight to the solvation mechanism of tested compounds. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . To examine the establishment of Health Japan 21 regional plans according to the local community type.

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The isolation of electron-donor-binding RNA by in vitro selection (also known as SELEX) yielded an RNA aptamer that could increase the fluorescence intensity of the sensor by 13-fold. Two purposes of this study were to determine what percentage of adults who had had cerebrovascular accidents were able to dial and recall telephone numbers, and whether or not the device, the Dial-a-Phone, was an effective instrument to use to teach these patients to dial the telephone. Meta-analyses were done with random-effect models and heterogeneity was calculated with the I2 method. The disintegration behavior of paracetamol tablets was studied by magnetic resonance imaging (MRI) using the Snapshot FLASH method. Polyarticular presentation, disease activity, and damage predict progression of joint damage.

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Comparison of labeling patterns between experimental and control animals demonstrated extensive proliferation of novel PMv terminal fields and the appearance of retrogradely labeled cell bodies within area 1/2 of the primary somatosensory cortex after M1 injury. The occasional discovery of an epidermoid cyst of the spleen, rare kind of lesion, in a 25 years old man who underwent a US for urethral colic, permit to the authors a review of the literature.

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We conclude that cell salvage in orthopedic surgery decreases the proportion of patients requiring allogeneic blood transfusion perioperatively, but postoperative cell salvage is only marginally effective in cardiac surgery. Tissue engineering has been defined as the application of principles and techniques of the life sciences and engineering to the design, modification and growth of living tissues using biomaterials, cells and growth factors, alone or in combination. The site of absorption of orally administered Co60-labelled vitamin B12 in dogs: the effect of dose.

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Effects of cryopreservation on human sperm deoxyribonucleic acid integrity. Asymmetric Synthesis of Pyrrolidine-Containing Chemical Scaffolds via Tsuji-Trost Allylation of N-tert-Butanesulfinyl Imines. Donors were categorized by age, sex, and cumulative number of granulocyte donations. Vectors based on the adeno-associated virus (AAV) have attracted much attention as potent gene-delivery vehicles, mainly because of the persistence of this non-pathogenic virus in the host cell and its sustainable therapeutic gene expression. Weaning from mechanical oxybutynin er tab ventilation--the team approach and beyond.

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Retention of information under conditions approaching a steady state. Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard. To determine the association of BD and coagulation-fibrinolysis pathway activation. Histopathological analysis of four autopsy cases of HTLV-I-associated myelopathy/tropical spastic paraparesis: inflammatory changes occur simultaneously in the entire central nervous system. synthesis of cyclophosphamide administration Plasma norepinephrine and dopamine-beta-hydroxylase in genetic hypertensive rats.

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Immune modulation in autologous bone marrow transplantation: cyclosporine and gamma-interferon trial. Individuals who do not adhere to their treatment regimens may be at greater risk of suicide but these issues are relatively unexplored in primary care services. This may be due to induction of various defense mechanisms, such as an activation levothroid dosage strengths of lisinopril of P-glycoprotein, which develops throughout the life and protect the human against xenobiotics. To detect the periodontal status of male smokers and betel chewers in a rural community in Sri Lanka and compare it with that of male non-tobacco users of the same community.