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Lamotrigina (Lamotrigine)

Lamotrigina is currently indicated as adjunctive therapy for focal and generalized tonic-clonic seizures and for treatment of bipolar disorder and neuropathic pain. A common concern with LTG in children is the frequency of appearance of skin rash. The intensity of this adverse effect can vary from transient mild rash to Stevens–Johnson syndrome (SJS), which can be fatal mainly when LTG is coadministered with valproic acid (VPA). Hereby, we present the case of an 8-year-old boy who suffered from SJS and other complications two weeks after LTG was added to his VPA treatment in order to control his seizures. VPA is known to decrease LTG clearance via reduced glucuronidation. In this case, the minor elimination pathway of LTG would play a more important role, and the formation of an arene oxide metabolite would be enhanced. As this reactive metabolite is detoxified mainly by enzymatic reactions, involving microsomal epoxide hydrolase and/or GSH-S-transferases and these enzymes are polymorphically expressed in humans, arene oxide toxicity is increased when epoxide hydrolase or GSH-S-transferases is either defective or inhibited or a depletion of intracellular glutathione levels is taking place. VPA can cause inhibition of epoxide hydrolase enzymes and/or depletion of glutathione levels leading to adverse cutaneous reactions.

Other names for this medication:
Lamotrigine, Lamictal, Daksol, Epitec, Flamus, Labileno, Lafigin, Lamal, Lambipol, Lamez, Lamictin, Lamidus, Lamirax, Lamitor, Lamitrin, Lamogine, Lamolep, Lamotrigin, Lamotrigina, Lamotrix, Lomarin, Meganox,

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Cibadrex, Voltadex, Norpress, Klomifen, Robaz, Imped, Aristogyl, Amlovasc, Sitavig, Acimax, Prandin, Biocid, Procor, Malival, Gastrolan, Ospamox, Novotrim, Audazol, Controloc, Antinaus, Vagimid, Daonil, Divarius, Vesdil, Lyosan, Tenvir, Klomeprax, Indocin, Monocor, Naxy, Metco, Fordex, Urisol, Sepram, Spirolon, Ceprandal, Afungil, Paroxat, Lansor, Aramix, Dhatrin, Wormkuur, Orfarin, Novofen, Fender, Ansiten, Akorazol, Resto,

Lamotrigina is used alone or together with other medicines to help control certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. It can also be used in the treatment of bipolar disorder (manic-depressive illness) in adults.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Tablet, Extended Release
  • Tablet, Chewable
  • Tablet, Disintegrating

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Relative effectiveness of electric shock and priase and reproof in verbal conditioning. A 74-year-old woman developed vertigo and jerk nystagmus to the left with normal cerebral imaging. We assessed the clinical knee score and bone mineral density of the proximal tibia in an attempt to evaluate the efficacy of valgus knee bracing. In the present study we investigated the effects of a thyroid hormone, thyroxine, on energy coupling of intact rat thymus lymphocytes and mitochondria isolated from these cells.

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Preliminary studies on the total alkaloids from the seeds of Alangium lamarckii Thw. On the treatment of the varicose symptom complex and its sequelae with Perivar We determined the concentrations of all amino acids in plasma of patients with MSUD during crises (with severe CNS symptoms) and after recovery in the hope of detecting possible alterations of these levels during metabolic decompensation. Incident analysis instead of punishment has resulted in improved patient safety in the USA An outline of the many aspects of preoperative evaluation of dermatologic surgery patients is presented.

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Comparison of three DNA marker systems for assessing genetic diversity in Asian arowana (Scleropages formosus). Recent work has established that TPQ biogenesis proceeds via a novel self-processing pathway requiring only the protein, copper, and molecular oxygen. Patient-centered Radiology: Where Are We, Where Do We Want to Be, and How Do We Get There?

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In the past, investigators have demonstrated a decline in plasma fibronectin levels following cardiac operation and have assumed that RES function was impaired. Our preclinical and ongoing clinical studies indicated that eradication of host immunohematopoietic cells, including chemoradiotherapy-resistant leukemia, could be achieved by adoptive allogeneic cell therapy with donor lymphocyte infusion following induction of host-versus-graft transplantation tolerance mediated by engraftment of donor stem cells in the course of BMT.

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Forced-air warming is recognized as an effective procedure to prevent hypothermia. Occurrence of mirtazapine-induced delirium in organic brain disorder. We utilized human cardiac microvascular endothelial cells (HCMECs) and altered ERK5 expression using siRNA mediated gene silencing or overexpression of constitutively active MEK5 and ERK5 to reveal a role for ERK5 in regulating endothelial tight junction formation and cell permeability. Progesterone prevented culture-induced increase in ESR1 expression. In addition, the analyses of PSI stability in Pyg7RNAi plants showed that Pyg7 is involved in maintaining the assembled PSI complex under excess-light conditions.

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A further accompanying article reviews some of the educational methodology and innovations in teaching and learning that may be applied to dentistry. Long-term potentiation (LTP) is the most widely studied form of neuroplasticity and is believed by many in the field to be the substrate for learning and memory. They described little or no teaching of clinical skills to identify and manage suffering and desired such training. The BMP inhibitors noggin and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes.

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Finally, post-operative images of patients who were doing well after being operated without pre-operative planning were compared with retrospective planning to check the necessity of the hypothesis in obtaining good functionality of the neolarynx. These polyvalent and safe Bt strains could be very promising in field application.

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Female wild-type (WT) mice, NOS3-deficient mice (NOS3-/-), NOS3-/- mice with cardiomyocyte-specific overexpression of NOS3 (NOS3-/-CSTg), and mice deficient for soluble guanylate cyclase alpha1 (sGCalpha1-/-) were subjected to potassium-induced cardiac arrest (9 min) followed by CPR. However, there is scant work on deep cervical flexors performance in subjects with chronic nonspecific neck pain. Several doubtfully pathological k-values were recorded in women more than 40 years of age.

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The above results suggest that intensive imaging assessment might be very important for successful MICS operations with ministernotomy or minithoracotomy and that extensive indications for this technique exist for various cardiovascular diseases. Cutaneous reactive angiomatosis associated with chronic lymphoid leukemia. Morphological observation of cone biopsy and hysterectomy specimens of high-grade cervical intraepithelial neoplasia Could carnosine be a naturally-occurring scavenger for acrolein and other reactive aldehydes in the brain? Torsional potentials and full-dimensional simulation of electronic absorption and fluorescence spectra of para-phenylene oligomers using the semiempirical self-consistent charge density-functional tight binding approach.

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Subjects were asked to imagine happy and sad situations with and without visualizing other people. Deletion of the Phe or Tyr residue at position 3 or 18, respectively, decreased the efficiency of translocation of STIp across the outer membrane. The progress of leukoaraiosis is greatly inhibited by long-term correction of platelet hyper-aggregability. Then they added dental caries, large restorations, fractures and periapical pathosis to the radiographs. Eleven of 30 patients with middle or lower third thoracic esophageal squamous cell carcinoma had thoracic paratracheal lymph node metastasis.

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Adenomas were lined by epithelium of differing cells types, ranging from a flat singly ciliated form to cuboidal-columnar types, or to mixed cell populations. In particular, segregation between non-Hispanic white students and all other students has increased, on average, while segregation among black, Hispanic, and Asian student groups has declined. Whereas some cases are cured during childhood, most patients instead undergo palliation, which leaves them at risk for late complications. Oxidation of shortchain fatty acids (C1-C8) by ram, bull, dog and fowl spermatozoa.

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Formants of children, women, and men: the effects of vocal intensity variation. Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum. We conducted a 4-year follow-up of a cross-sectional study in a cohort of 280 stable hemodialysis patients. Recognizing objects seen from novel viewpoints: effects of view similarity and time. Immunogenicity and safety of a tetanus toxoid, reduced diphtheria toxoid and three-component acellular pertussis vaccine in adults 19-64 years of age.

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PIK3Ca-Related Overgrowth Syndromes encompass Klippel-Trenaunay, Congenital Lipomatous Asymmetric Overgrowth of the Trunk with Lymphatic, Capillary, Venous, and Combined-Type Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and Spinal Anomalies, Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome (M-CAP), fibroadipose hyperplasia, and macrodactyly. Transduction of Bcl-XL in our study led to significant rescue of RGCs indicating the relevance of this pathway for neuronal survival under autoimmune inflammatory conditions. Data was prospectively recorded for all patients who had carotid endarterectomy between 1997 and 2006 in our vascular surgical unit. The p14 alternate reading frame (ARF) tumor suppressor plays a central role in cancer by binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA damage and oncogene activation. The time of peak Bmal1 expression remained LP-like, whereas Cry1 expression was continually low.

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Hydatid disease is an important medical problem in countries of the temperate zones. Although similar studies investigating the role of cigarette exposure in susceptibility to SSc have been rarely reported and specific mechanisms have never been established, the relationship between smoking and some SSc-related symptoms have been demonstrated during the last decade. In addition, we have newly determined several human, rat, pig and dog CAR-mRNA sequences. Short- and long-term outcomes of interest for this review were poorly reported.

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The coefficients of determination for explaining variation in tenderness rating using sarcomere length, collagen concentration, and desmin degradation for raw and cooked samples were 0.43 and 0.73 (beef) and 0.48 and 0.57 (pork), respectively. Our data confirm and extend former reports concerning the PERV infection of human cells. We investigated the effects of guanidine hydrochloride (GuHCl) and high pressure on the conformational flexibility of the active site of sweet potato beta-amylase by monitoring the sulfhydryl reaction and the enzymatic activity. These results are compared to those obtained from whole-tissue extract and apoplastic fluid.

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A homogeneous, fluorescence resonance energy transfer (FRET)-based DNA polymerase assay that is suitable for high-throughput screening for inhibitors, and can also be used for steady-state kinetic investigations, is described. Clinical results were satisfactory except in one patient, who died as a result of a pulmonary embolism that occurred 10 days after surgery. Although race does not affect left ventricular mass or the prevalence of left ventricular hypertrophy, black race is associated with greater relative wall thickness, itself a predictor of unfavorable cardiovascular outcome.

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growing wild in Oman have been established by (13)C-NMR analyses of the vegetative and floral oils of the plants. With the help of real-time PCR it is possible to test DNA samples for these influencing factors. Since current pharmacotherapy for behavioural problems in dementia has very modest effects at the risk of serious adverse effects, non-pharmacological interventions must be encouraged. The individual irritants could be differentiated due to different time courses of their skin irritation. Furthermore, some cytokines and chemokines released in response to infection and/or intoxication can modulate different stages of neurogenesis (proliferation, migration, and differentiation).

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BG levels were assessed from the preoperative period to the end of postoperative day 2. In multivariate analyses treatment content and timing had an independent effect on survival.

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A synthetic tail peptide of 10 amino acids could replace HslU in supporting the HslV-mediated hydrolysis of unfolded polypeptide substrates such as alpha-casein, as well as of small peptides, suggesting that the HslU C terminus is involved in the opening of the HslV pore for substrate entry. Manipulations of the dorsal raphe nucleus (DRN) modulate the behavioral effects of exposure to inescapable shock (IS). Phenelzine as a stimulant drug antagonist: a preliminary report.

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A new formula for continuous medication in the asthmatic patient. Hyrcanoside was also tested in the PS mouse leukemia assay and showed borderline activity. In the spouse-rated set, more punishing responses to subject illness behavior were associated with greater tinnitus-related role dysfunction. The hepatic artery system and its relation to the portal system in the dog liver In this study, we investigated whether other SLC6A4 single nucleotide polymorphisms (SNPs) are associated with drinking intensity among treatment-seeking alcoholics and whether these polymorphic variants result in differential SLC6A4 expression levels.

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Furthermore, the model predicts an acoustic SL of 89 (79-99) dB with regard to microPa rms reference 1 m for pulses emitted by herring in a natural shallow water environment at unknown distance corresponding to a flow rate of 2.5 ml/min. Gastroduodenal opportunistic infections and dyspepsia in HIV-infected patients in the era of Highly Active Antiretroviral Therapy. On the basis of their findings, the authors make recommendations for future reentry programs. Only change in depression predicted improvement in interpersonal relationships throughout treatment. Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors.

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In particular, closer attention must be paid to the indications for and duration of warfarin treatment. Patients with more than two revisions seem to have a higher chance of developing seizures. Spectro-temporal analysis of complex tones: two cortical processes dependent on retention of sounds in the long auditory store. Inflammatory processes are made up of a multitude of complex cascades.

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Here, we show that an atomic force microscope tip modified with 27-acid dendron, a cone shaped molecule with 27 monomeric units forming its base, can be successfully used to map the spatial distribution of mouse Pax6 mRNA on sectioned tissues of the mouse embryonic neocortex. Monolayer As-graphane is constituted by using As adsorbing on graphane with honeycomb H vacancies. In these studies we examine changes in the expression of several transcription factors in the spinal cords of morphine tolerant C57BL/6 mice.

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This study concerns the immunohistochemical localization of S-100 alpha, S-100 beta, and whole brain S-100 (wbS-100) in testicular large-cell calcifying Sertoli cell tumor (LCCSCT). The cells were mounted in a water-tight barrier between two chambers containing reversible electrodes for the application of potentials, and fitted with calibrated capillaries to measure water movement.

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To assess antibody labeling of ciliary muscle structures, additional sections were double-immunostained using antibodies to collagen type I and calponin and examined by confocal microscopy. Such an adjustment was investigated from the technological standpoint including starter culture performance, chemical and physical properties of manufactured Greek yoghurt and generated acid whey. Furthermore, altered expression was observed for certain genes implicated in governance of aging and lifespan in other organisms suggesting intriguing commonalities across species.

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Thus, measurements and analysis of NMR relaxation data can provide structurally resolved information on self-association that would not be accessible otherwise. Gene expression changes reveal patterns of aging in the rat digestive tract. Introduction of innovative cardiac procedures mostly depends on extensive evaluation using laboratory animal models.

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However, the inability of indomethacin to reverse the inhibitory effect of glycocalyx on LPS-induced nitric oxide generation suggests that the selective modulation of macrophage function by glycocalyx may be more complex than increased sensitivity to PGE2 feedback inhibition. The RID for methylprednisolone was lower than the generally accepted value.

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Two protocols developed for the Tonal and Speech Materials for Auditory Perceptual Assessment audio compact disc are low- and high-pass filtered versions of the Northwestern University Auditory Test No. Adrenalectomy can provide excellent palliation of the symptoms of cortisol excess and can dramatically improve patient quality of life, but both patients and physicians must know that these changes may take years.

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Haplotype analysis of two Irish families with this mutation supports the hypothesis that Celtic chromosomes represent an extensive portion of cystinosis chromosomes in French Canada. Both the laparoscopic transcystic approach and choledochotomy are discussed, together with the results given in the literature. The adsorption of two alkaloids by activated attapulgite, halloysite, and kaolin.

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Fears and concerns expressed by families in the donation discussion. The results obtained were compared with those of other workers on other muscles. Tumor growth suppression is achieved by a combination of direct induction of tumor cell apoptosis and down regulation of tumor VEGF with decreased angiogenesis Periodical determinations of either serum IgG or the subclasses may be useful in the follow-up of these patients.

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In addition, information on both isolated tumor cells and micrometastases is useful not only for staging but also for considering an adjuvant treatment schedule. To better understand its function on membrane integral or bound enzymes, DNA origami and frame-guided assembly strategy are combined to construct a given-size, addressable enzyme-containing nanomembrane as a heterogeneous reactor to explore the enzymatic catalyst reaction on the membrane. Non-obstructive drainage-tube with a mandrin for the drainage of thoracic and mediastinal cavities Excisional biopsy was performed under the impression of a malignant neoplasm, and the pathologic diagnosis confirmed squamous cell carcinoma. The Lung-molGPA score was calculated as described by Sperduto et al.

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The structure of rostral teeth and the rostrum of Pristis microdon. Following high-dose UV-irradiation, p53 accumulated in the cytoplasm and led to activation of the pro-apoptotic protein Bax. The addition of Brij 35 to the charged micelle was effective in improving the correlation because the surface charges of the micelle were shielded. The ultimate goal of identifying all the genes on the X chromosome whose mutations cause mental retardation will require a concerted effort between clinical and molecular investigators.

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Outcomes were examined to determine whether specific plating technology affected the incidence of plate-related complications including plate exposure, plate fracture, and plate removal. Greyhounds had a positive phase across the stifle, tarsal, and MTP joints at the end of stance for an active push-off, whereas for the Labrador Retrievers, the only positive phase was across the tarsus, and this was small, compared with values for the Greyhounds.

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A 57-year-old man with chronic active hepatitis, a rapidly progressive bullous eruption, and shock. Endocervical staining with toluidine blue is highly useful for diagnosis of superficial cervical invasion by endometrial carcinoma. Principles of physiotherapeutic management of shoulder impingement syndrome. Among them, the risk to progeny after irradiation of their parents is a major concern. Standard errors and confidence intervals for correlations corrected for indirect range restriction: A simulation study comparing analytic and bromocriptine after pregnancy bootstrap methods.

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We studied 14 patients who underwent radical retropubic prostatectomy for prostate cancer. General practice patients consulting because of a new episode of LBP completed questionnaires on pain-related fear, avoidance, pain and disability. Olomoucine inhibits in vitro M-phase-promoting factor activity in metaphase-arrested Xenopus egg extracts, inhibits in vitro DNA synthesis in Xenopus interphase diazepam uk suppliers egg extracts and inhibits the licensing factor, an essential replication factor ensuring that DNA is replicated only once in each cell cycle. Tumor necrosis factor-alpha decreases pulmonary artery endothelial nitrovasodilator via protein kinase C.

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A layered organization of cells is a common architectural feature of many neuronal formations. Unlike other bacteria, little is known about artrigesic piroxicam 20 mg the genetics and biochemistry of exopolysaccharides in Azospirillum brasilense.

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The goal of the work was to develop a WWW-oriented computer system providing a maximal integration of informational and software resources on the regulation of gene expression and navigation through them. Previous studies concluded that FB1 induced apoptosis or cell-cycle arrest in CV-1 cells (African green monkey kidney fibroblasts). Effects of estradiol benzoate and testosterone on the genital apparatus of Bufo bufo tadpoles Empirical evidence relating to the theoretical perspective of the techniques has shown that there are carvedilol 25mg vs losartan problems with all techniques in terms of descriptive validity.

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Cardiovascular reactivity did not mediate the stress-distress or stress-illness associations. The pinamox dosage forms mobility of Al and Cu in the soil column was closely related to the solubility and transport of the DOM in soil solution. This is one of the obligations concerning donation and procurement mentioned in the European Commission directives on tissue banking. While they have partly achieved their objective, clinics for young addicts, created ten years ago and aimed specifically at this section of the population, still struggle to reach out to certain teenagers, notably those with issues relating to alcohol consumption. However, unlike the erythrocyte, there are approximately 2000 actin monomers per tropomodulin in the lens.(ABSTRACT TRUNCATED AT 250 WORDS)

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A case of bilateral Achilles tendon rupture associated with steroid use is reported. Professional associations and societies in the field of dermatology, diabetology, gastroenterology and rheumatology in the UK, between 8 August 2016 and 8 January 2017. A second round of amplification utilising generic labelled primers targeting the vector and unlabelled locus-specific primers targeting the microsatellite flanking region yield allelic profiles that are representative of all individuals contained within the pool. The use of a new long-acting progestational compound (17-alpha-hydroxyprogesterone-capronate) in infertility and habitual abortion. The APRR1 protein is identical to the one that was recently suggested to interact with the ABI3 l adelchi trama yahoo kids (ABISCISIC ACID INSENSITIVE3) protein.

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Quantitative parameters such drug interactions with tramadol and cymbalta interaction as maximum flow velocity, pulsatility index, and resistive index were also assessed. On the basis of a variety of 23 molecular descriptors including those obtained by quantum-chemical calculations, multiple regression analysis and discriminant analysis were applied to identify the significant factors contributing to the flow patterns.

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Temporal and spatial variation of trace metals anticol max an aesthetic drug in clams Tivela mactroidea along the Venezuelan coast. Upon illuminating the chlorophyll a (Chl)-coated mercury electrode with an appropriate light source, the photocurrents generated by the Chl aggregates are measured under short-circuit conditions in the absence of photoartefacts. The data suggest that at least four intermediates are formed as the pH is increased prior to complete unfolding of the protein. Epitope mapping of an anti-FN monoclonal antibody that inhibits FN-mediated adhesion identified the same critical regions.